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KMID : 1134820190480010024
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 1 p.24 ~ p.31
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Protective Effect of Fingerroot Ethanol Extract and Its Water Fraction against UVB-Induced Skin Photoaging in Human Skin Fibroblasts
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Yeon Da-Som
Lee Ha-Na
Song Jin-Hee
Yang Jin-Woo
Kim Young-Hwa
Jeong Heon-Sang
Lee Jun-Soo
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Abstract
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The protective effects of various solvent extracts and ethanol fractions from fingerroot were evaluated against UVB-induced photoaging in human skin fibroblasts. The ethanol extract of fingerroot showed cytoprotective effects but high toxicity when treated at 2 μg/mL or more. Therefore, we partitioned the ethanol extract into chloroform, ethyl acetate and aqueous fractions. Among these fractions, the water fraction from the ethanol extract showed dose-dependent protective effects with no cytotoxicity up to 20 μg/mL. In addition, the water fraction effectively inhibited the mRNA expression and protein production of matrix metalloproteinase (MMP)-1 and MMP-3 induced by UVB irradiation and increased the intracellular collagen levels. In this study, the water fraction of fingerroot ethanol extract exhibited skin protective effects against photoaging induced by UVB.
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KEYWORD
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photoaging, fibroblast, collagen, matrix metalloproteinase, fingerroot
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